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The following doses of the combination treatment (Polyalthic acid + naproxen) were orally administered to rats evaluated with carrageenan-induced hyperalgesia. The results were used to construct a dose–response curve.
| Combination | Oral Dose (mg/kg) | ||
|---|---|---|---|
| Polyalthic Acid | Naproxen | Total Dose in the Combination | |
| 1 | 3.2 | 0.6 | 3.8 |
| 2 | 6.4 | 1.3 | 7.7 |
| 3 | 12.7 | 2.5 | 15.2 |
| 4 | 25.4 | 5.0 | 30.4 |
| 5 | 50.8 | 10 | 60.8 |
