Figure 4.

Structure of ANX. (A) Schematic representation of ANX. The four repeat sequences of the core domain fold into a curved-shape disk. The convex face binds Ca²⁺ (blue spheres) and interacts with membrane. The N-terminal domain varies between ANX and regulates their function by interacting with other proteins. (B) Representation of the tertiary structure of ANX. Image of 1AVH (human ANXA5) [103] created with MMDB [104]. (C) Schematic representation of molecular interactions between ANX, Ca²⁺, and membrane.