Table 1.
Overview of proteins involved in sarcolemma repair.
Protein | Symbol | Function | Binding Partners | Ref |
---|---|---|---|---|
Annexin A1 | ANXA1 | The “lipid patch” formation | DYSF, S100A11 | [40,41,42,43] |
Annexin A2 | ANXA2 | The “lipid patch” formation | DYSF, S100A10 | [40,41,42,43] |
Annexin A4 | ANXA4 | To be established | To be identified | [44] |
Annexin A5 | ANXA5 | Strengthening the damaged membrane | To be identified | [24,45] |
Annexin A6 | ANXA6 | Condensing membranes at the disruption site | To be identified | [26,29,46,47] |
Annexin A7 | ANXA7 | To be established | To be identified | [48,49] |
Anoctamin-5 | ANO5 | To be established | To be identified | [50,51,52,53,54] |
Calpains | CAPN1-3 | The formation of mini-dysferlinc72 | DYSF | [55,56,57,58] |
Caveolin-3 | CAV3 | Controlling membrane tension | DYSF, MG53 | [59,60,61,62,63,64,65] |
Dysferlin | DYSF | Recruiting the “lipid patch” | ANXA1, ANXA2, Calpains, CAV3, MG53 | [8,9,40,46,55,59,66,67,68,69,70] |
Mitsugumin-53 | MG53 | Strengthening the damaged membrane and recruiting the “lipid patch” | DYSF, CAV3 | [65,70,71] |