Table 1.
Effects of 8-Br on ventricular arrhythmias during regional ischaemia and reperfusion.
| Parameters | C-Pre (n = 7) | 8-Br-Pre (n = 5) | C-Post (n = 6) | 8-Br-Post (n = 7) | |
|---|---|---|---|---|---|
| Regional Ischaemia | Number of VPBs | 830 ± 194 | 401 ± 126 | 738 ± 193 | 856 ± 267 |
| Number of VT/VF | 38 ± 15 | 3 ± 1 * | 77 ± 27 | 39 ± 15 | |
| Arrhythmia Score | 6.8 ± 0.2 | 5.0 ± 0.8 * | 6.8 ± 0.2 | 6.7 ± 0.3 | |
| Reperfusion | Number of VPBs | 409 ± 117 | 160 ± 62 | 211 ± 77 | 249 ± 62 |
| Number of VT/VF | 10 ± 2 | 3 ± 1 * | 9 ± 2 | 3 ± 1 * | |
| Arrhythmia Score | 6.3 ± 0.2 | 4.8 ± 0.4* | 6.4 ± 0.3 | 4.7 ± 0.6 * | |
8-Br-Pre—a group of hearts treated with 10 μM 8-Br at the end of preischaemia. 8-Br-Post—a group of hearts treated with 10 μM 8-Br at the end of regional ischaemia. C-Pre and C-Post—control groups of hearts corresponding to 8-Br-Pre and 8-Br-Post. The data are presented as the mean ± SEM. * p < 0.05 vs. control (C-Pre or C-Post, respectively).