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. 2021 May 15;13(5):916. doi: 10.3390/v13050916

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Assessment of seasonal human coronavirus cellular immunity in convalescent COVID-19 donors. (A) Magnitude of 229E spike protein-specific cellular immunity in all study participants split by duration of self-report COVID-19 symptoms. (B) Magnitude of NL63 spike protein-specific cellular immunity in all study participants split by duration of self-report COVID-19 symptoms. (C) Correlation table assessing the relationship between NL63, 229E, and SARS-CoV-2 spike protein reactivity in all subjects and the magnitude of reactivity against other human coronavirus antigens included in the study. r² and p value calculated by 2-tailed Pearson Correlation test. (D) Relationship between subject age and total 229E/NL63 spike protein-specific cellular immune response. Filled circles indicate subjects included in the short duration of symptoms group. Empty circles indicate individuals included in the long duration of symptoms group. r² and p value calculated by 2-tailed Pearson Correlation test.