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. 2021 May 17;22(10):5281. doi: 10.3390/ijms22105281
IVD intervertebral disc
ATP adenosine triphosphate
HIF-1α hypoxia-inducible factor-1 alpha
NP nucleus pulposus
AF annulus fibrosus
CEP cartilaginous end plate
GAG anionic glycosaminoglycan
PHD prolyl 4-hydroxylase domain-containing
VHL von Hippel–Lindau tumor suppressor
HRE hypoxia responsive element
FIH-1 factor inhibiting HIF-1
C-TAD C-transactivation domains
FasL Fas ligand
ECM extracellular matrix
GLUT glucose transporter
ANK ankylosis protein homolog gene
VEGF vascular endothelial growth factor
VEGFR vascular endothelial growth factor receptor
AMPK adenosine 5′-monophosphate-activated protein kinase
mTOR mechanistic target of rapamycin