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Dedifferentiated and periosteal chondrosarcoma. The transition to undifferentiated pleomorphic sarcoma ((A), HE, 200×), the case was positive with p.Arg132His mutation-specific isocitrate dehydrogenase 1 ((IDH1), 200×) antibody and negative for isocitrate dehydrogenase 2 ((IDH2), 200×); periosteal chondrosarcoma and cortical extension to soft-tissue ((B), HE, 40×). Photos by Anna Szumera-Ciećkiewicz.
