Table 3.

Association of MA changes with DR severity progression over 5-years of follow-up.

ETDRS Severity Changes	MA Turnover 12 m (Mean ± SD Median [Q1–Q3])	MA Formation Rate 12 m (Mean ± SD Median [Q1–Q3])	MA Disappearance Rate 12 m (Mean ± SD Median [Q1–Q3])
Worsening (n = 61) (≥1 or 2 steps progression)	2.9 ± 3.8, 2 (1–4)	1.6 ± 2.2, 1 (0–3)	1.3 ± 2.1, 1 (0–2)
Improvement or Maintenance (n = 101)	2.3 ± 4.1, 1 (0–2)	1.1 ± 2.4, 0 (0–1)	1.2 ± 2.2, 0 (0–1)
p value *	0.035 *	0.033 *	0.316

* and bold values represent statistically significant alterations, with p < 0.05. Mann–Whitney U test. Worsening = 1-or more-step worsening in ETDRS classification.