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. 2021 May 27;57(5):2002559. doi: 10.1183/13993003.02559-2020

FIGURE 4.

FIGURE 4

Biomarker changes in plasma. PDGF: platelet-derived growth factor; AM: alveolar macrophage; PAI: plasminogen activator inhibitor; Gal: galectin; CCL: chemokine (C-C motif) ligand. a, c, e, g, i) Percentage of baseline at day 14 for a) PDGF-BB, c) PAI-1, e) Gal-3, g) CCL18 and i) YKL-40 in the 0.3, 3 and 10 mg TD139 dose groups or placebo. Boxes indicate median and interquartile range; whiskers indicate minimum–maximum range. p-value from ANCOVA model adjusted for baseline. b, d, f, h, j) Correlation between percentage of baseline in b) PDGF-BB, d) PAI-1, f) Gal-3, h) CCL18 and j) YKL-40 versus the change in lung macrophage Gal-3 expression in the placebo and 10 mg TD139 groups. Dotted line shows no change from baseline. Fisher's exact test for percentage of baseline <100% for plasma Gal-3 and AM Gal-3 expression (yes/no) versus treatment group (placebo, 10 mg) p=0.031.