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. 2021 May 17;22(10):5272. doi: 10.3390/ijms22105272

Figure 4.

Figure 4

Glial fibrillary acidic protein (GFAP) immunohistochemistry in the Cornu ammonis (CA1) hippocampal zone at different magnifications. The increase in GFAP expression and changes in astrocyte morphology is more pronounced in ASH (B,F,J,K,L). Animals exposed to IHH had greater GFAP expression but did not show astrogliosis (C,D,G,H). Bars represent the following distances: ((A)–(D)), 100 µm; ((E)–(H)), 40 µm; (I,J), 20 µm; (K,L), 15 µm. Animal experimental groups are abbreviated as NOR, normoxic; ASH, acute severe hypoxia; IHH, intermittent hypobaric hypoxia; IHH+ASH, intermittent hypobaric hypoxia followed by acute severe hypoxia.