Figure 6.

Experimental design and hypoxia exposure protocols. Animal experimental groups are abbreviated as NOR (normoxic), maintained at sea level conditions for the whole experiment; ASH (acute severe hypoxia), exposed to normobaric hypoxia at 7% O₂ for a single 6 h continuous session; IHH (intermittent hypobaric hypoxia) exposed to hypobaric hypoxia (4000 m) for 8 consecutive days for 4 h sessions per day; and IHH+ASH, exposed to the intermittent hypobaric hypoxia protocol followed by a single session of acute normobaric hypoxia. Brain extraction was carried out after 6 h of normoxia in NOR and IHH or immediately after 6 h of acute hypoxia in ASH and HII+ASH. Yellow boxes and arrows indicate time spent in normoxia; red boxes are acute normobaric hypoxia sessions, and blue boxes time spent in hypobaric hypoxia.