Table 3.
Univariate and multivariate analysis of factors associated with clinical failure at seven days.
| OR (95%CI) | p-Value * | Adjusted OR | p-Value ** | |
|---|---|---|---|---|
| Sex, male | 1.230 (0.626,2.415) | 0.548 | 1.182 (0.501,2.785) | 0.702 |
| Age > 77 | 1.155 (0.886,1.505) | 0.286 | 1.129 (0.856,1.487) | 0.388 |
| Infectious diseases intervention | 1.676 (0.891,3.154) | 0.109 | ||
| Pharmacy intervention | 1.683 (0.681,4.161) | 0.259 | ||
| Previous antibiotic | 1.314 (0.700,2.465) | 0.396 | 1.763 (0.756,4.114) | 0.189 |
| Immunosuppressive treatment | 2.001 (1.052,3.805) | 0.034 | ||
| Urinary catheterization | 0.505 (0.159,1.609) | 0.248 | ||
| Other catheters | 0.157 (0.020,1.248) | 0.080 | ||
| Previous urological manipulation | 0.280 (0.092,0.851) | 0.025 | ||
| Urological pathology | 0.543 (0.270,1.089) | 0.086 | ||
| History of recurrent UTIs | 1.092 (0.572,2.084) | 0.790 | ||
| Diabetes | 0.679 (0.360,1.280) | 0.231 | ||
| Urological neoplasms | 0.176 (0.051,0.609) | 0.006 | ||
| McCabe–Jackson Index > 2 | 0.899 (0.684,1.181) | 0.446 | 1.108 (0.848,1.447) | 0.451 |
| Charlson Comobilidity Index > 5.8 | 1.062 (0.862,1.308) | 0.571 | 1.695 (0.921,3.120) | 0.090 |
| Bacteremia | 1.936 (1.006,3.724) | 0.048 | 2.412 (0.351,16.538) | 0.370 |
| Cystitis | 1.018 (0.485,2.138) | 0.962 | 1.656 (0.562,4.877) | 0.360 |
| Pyelonephritis | 0.410 (0.192,0.875) | 0.021 | 0.782 (0.246,2.487) | 0.678 |
| Prostatitis | 0 (0,0) | 0.999 | ||
| Confusion syndrome associated with UTIs | 2.215 (1.142,4.296) | 0.019 | 5.155 (1.670,15.906) | 0.004 |
| Sepsis | 2.275 (1.163,4.451) | 0.016 | 3.758 (0.519,27.208) | 0.190 |
| Shock | 3.964 (0.705,22.306) | 0.118 | 7.239 (1.008,51.983) | 0.049 |
| ESBL | 2.645 (1.376,5.084) | 0.004 | 2.622 (1.086,6.328) | 0.032 |
| Time to adequate treatment | 1.359 (1.092,1.692) | 0.006 | 1.364 (1.059,1.755) | 0.016 |
| Appropriate empirical treatment | 0.217 (0.106,0.443) | <0.001 | ||
| Duration of hospital treatment | 1.285 (1.161,1.422) | <0.001 | ||
| CA-UTI | 0.997 (0.528,1.881) | 0.993 |
* Univariate analysis: Student’s t-test or Mann–Whitney U used for comparing quantitative variables. The Chi-square test was used for comparing qualitative variables. ** Multivariate analysis: binary logistic regression through the forward stepwise approach; ESBL: extended spectrum betalactamases; CA-UTI: Community-Acquired Urinary Tract Infection; OR: odds ratio.