Figure 5.

Schematic of in vitro transdifferentiation potential in the jellyfish Podocoryne. After collagenase treatment to isolated striated muscles from medusa umbrella, muscle cells begin to aggregate. Aggregated striated muscles transdifferentiate into smooth muscle cells by the degradation of striated myofiber and the formation of flagella, which eventually form an endoderm and undergo morphogenesis into a manubrium.