TABLE 1.
Non-compartmental PK parameters after the oral administration of KM (0.28, 1.4, or 7.0 mg kg−1) in naïve and STZ-induced DNP rats (n = 6).
| Parameters a | Administered dose | |||||
|---|---|---|---|---|---|---|
| 0.28 mg kg−1 | 1.4 mg kg−1 | 7.0 mg kg−1 | ||||
| Naïve | DNP | Naïve | DNP | Naïve | DNP | |
| Tmax (h) | 0.34 ± 0.11 | 0.22 ± 0.04 | 0.14 ± 0.06 | 0.36 ± 0.07 | 0.21 ± 0.06 | 0.21 ± 0.06 |
| AUC0-∞ (ng h ml−1) | 2.46 ± 0.85 | 8.10 ± 2.58††† | 7.35 ± 1.72 | 27.69 ± 6.68††† | 49.49 ± 8.53*** | 220.66 ± 23.64***,††† |
| t1/2 (h) | 0.82 ± 0.19 | 0.97 ± 0.35 | 1.10 ± 0.27 | 1.63 ± 0.44 | 2.46 ± 0.48** | 3.55 ± 1.36** |
| Vd (L kg−1) | 189.45 ± 51.77 | 70.36 ± 21.45††† | 304.92 ± 20.53 | 150.91 ± 53.53††† | 551.28 ± 110.56**,,††† | 182.06 ± 76.86**,,††† |
| CL (L h−1 kg−1) | 215.07 ± 89.02 | 68.49 ± 24.04††† | 248.24 ± 54.02 | 66.40 ± 13.62††† | 157.81 ± 19.74 | 33.41 ± 3.21††† |
a
Tmax, time to reach the maximum observed plasma concentration; AUC0-∞, area under the curve from time zero to infinity; t1/2, half-life; Vd, apparent volume of distribution; CL, clearance rate.
b
* represents p < 0.05, **represents p < 0.01, and ***represents p < 0.001 compared with 0.28 mg kg−1 or 1.4 mg kg−1 KM; †represents p < 0.05, ††represents p < 0.01, and †††represents p < 0.001 compared DNP rats with naïve rats in the same administered dose.