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Schematic models of the inhibition of PTENP1 expression by the YPB and OPB peptides. In breast cancer cells, YY1 recruits EZH2 and its associated PRC2 to mediate H3K27me3 in the PTENP1 promoter and repress its expression. YPB and OPB can bind either YY1 or EZH2, respectively, to disrupt the recruitment of EZH2 by YY1, leading to reduced H3K27me3 at the PTENP1 and its upregulation.
