Table 1.
Summary of GO and KEGG pathway enrichment analyses of the H3K27me3 changes in MDA-MB-231 cells treated by YPB and OPB peptides versus Cont peptide.
| GO Enrichment | |||
|---|---|---|---|
| Peptide (Gene Numbers) |
Biological Process (BP) |
Cell Component (CC) |
Molecular Function (MF) |
|
YPB (465) |
Sensory (eye and ear) system development, neuron migration. | Synaptic membrane and other membrane structures. | Voltage-gated ion channel activity. |
|
OPB (1137) |
Neural and reproduction system development. | Cell-cell junction, adhesion, neuronal cell development, microvillus. | Membrane channel activities, including ion and lipid transmembrane transportation. |
| KEGG Pathway Enrichment | |||
|
YPB (465) |
cAMP, MAPK, adrenergic, calcium, oxytocin signaling and cGMP−PKG pathways; regulations related to cardiac muscle, cholinergic synapse, and protein digestion and absorption. | ||
|
OPB (1137) |
RAP1, WNT, HIPPO and thyroid hormone signaling pathways; breast cancer, gastric cancer, liver cancer, and stem cell regulations. | ||