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. 2021 May 14;7(5):382. doi: 10.3390/jof7050382

Figure 1.

Figure 1

CD137 signaling protects the host from systemic C. albicans infection. (A–D) WT or Tnfrsf9−/− C57BL/6 mice were infected with 3 × 105 CFU C. albicans. (A) Survival rate (n = 5 mice per group). (B) Changes in body weight (n = 5 mice per group). (C,D) Mice were intraperitoneally injected with 200 μg of anti-CD137 or control rat IgG antibody 1 day before infection with 3 × 105 CFU C. albicans. (D) Survival rate (n = 6 mice per group). (D) Changes in body weight (n = 6 mice per group). (E) Serum creatinine and BUN levels (n = 5 mice per group). (F) Histopathological scores of 3-day post-infection kidney sections (n = 5 mice per group). Results are representative of at least three experiments. * p < 0.05; ** p < 0.01; *** p < 0.001 between the two groups.