Figure 5.
Neutrophils are required for anti-CD137-mediated enhancement of fungal clearance. (A,B) Neutrophils were isolated from WT mice and adoptively transferred to Tnfrsf9−/− mice (5 × 106 cells per mouse) immediately before injection with control or anti-CD137 antibody. Six hours later, mice were infected with 3 × 105 CFU C. albicans. (A) Survival rates (n = 5 mice per group). (B) Fungal burdens in 3-d post-infection kidneys. (n = 5 mice per group). (C) Survival rates of mice depleted of neutrophils (n = 6 per group). Fungal burden in kidneys (n = 5 mice per group). Results are representative of 3 experiments. * p < 0.05; *** p < 0.001 between the two groups or between the indicated group and the other 3 groups.