Table 2.

Top two SNPs from the gene and environment interaction analysis between 11,555 SNPs involved in estrogen metabolism and 8 environmental factors related to estrogen, Seoul Breast Cancer Study.

SNP	Chromosome	Position_b36	Gene	Minor/Major_Allele	MAF
rs13035764	2	24571432	NCOA1	G/C	0.2971
	N(Cases/Controls)	OR a (95%CI)	Analysis methods	Environment	p-2df	Threshold	p-GxE
	3925(1949/1976)	0.84 (0.76–0.93)	Weighted GE|2df	Age at menarche	1.2 × 10−3	0.005 b	0.0524
SNP	Chromosome	Position_b36	Gene	Minor/Major_Allele	MAF
rs851998	6	152025031	ESR1	A/G	0.4426
	N(Cases/Controls)	OR a (95%CI)	Analysis methods	Environment	p-2df	Threshold	p-GxE
	3940(1955/1985)	0.82 (0.75–0.90)	Subset GE|2df	height	6.8 × 10−5	0.000110 c	0.0471

^a risk of SNP for breast cancer; ^b threshold of bin 1 in the weighted model; ^c 0.05 divided by 456 SNPs which were tested in step 2.