Table 3.

Association between an environmental factor and breast cancer by genotypes.

Study	Exposure	Category	N(Cases/Controls)	OR	95% CI	p-GxE
SEBCS	Age at menarche < 14 years old a	Effect of E in overall	4022(1970/2052)	1.27	1.07–1.50	0.0524
		E|rs13035764_CC	1963(1007/956)	1.19	0.95–1.51
		E|rs13035764_CG	1706(810/896)	1.17	0.89–1.53
		E|rs13035764_GG	337(147/190)	2.85	1.43–5.67
	Height ≥ 160 cm b	Effect of E in overall	4022(1970/2052)	1.92	1.67–2.20	0.0471
		E|rs851998_GG	1281(677/604)	1.53	1.20–1.95
		E|rs851998_GA	1921(938/983)	2.03	1.65–2.49
		E|rs851998_AA	819(355/464)	2.39	1.74–3.29
BCAC-European	Age at menarche < 12 years old a	Effect of E in overall	62,485(36,894/25,591)	1.03	0.99–1.08	0.5314
		E|rs13035764_CC	9953(5921/4032)	1.02	0.91–1.14
		E|rs13035764_CG	34,124(20,140/13,984)	1.03	0.97–1.09
		E|rs13035764_GG	18,408(10,833/7575)	1.05	0.97–1.14
	Height ≥ 169 cm b	Effect of E in overall	56,363(31,994/24,369)	0.97	0.93–1.01	0.2425
		E|rs851998_GG	27,224(15,513/11,711)	0.93	0.88–0.99
		E|rs851998_GA	23,843(13,459/10,384)	0.99	0.93–1.05
		E|rs851998_AA	5296(3022/2274)	1.03	0.90–1.17
BCAC-Asian	Age at menarche < 12 years old a	Effect of E in overall	9047(4392/4655)	0.97	0.82–1.14	0.7817
		E|rs13035764_CC	4867(2407/2460)	0.95	0.75–1.21
		E|rs13035764_CG	3504(1666/1838)	0.99	0.76–1.28
		E|rs13035764_GG	676(319/357)	1.04	0.57–1.91
	Height ≥ 160 cm b	Effect of E in overall	5789(2879/2910)	1.22	1.08–1.39	0.4642
		E|rs851998_GG	1751(899/852)	1.20	0.95–1.52
		E|rs851998_GA	2846(1422/1424)	1.19	0.99–1.42
		E|rs851998_AA	1192(558/634)	1.38	1.04–1.82

ORs analyzed by logistic regression adjusting for age, family history, categorical FFTP, age at menarche, and menopausal status. ^a age at menarche <25% quartile; ^b height ≥75% quartile.