Table 4.
Multivariate logistic regression analysis of parameters predicting amoxicillin/clavulanate resistance in infected patients. Amoxicillin/clavulanate resistance in infected patients with E. coli or K. pneumoniae urinary isolate (n = 212; amoxicillin/clavulanate resistance episodes = 39).
| Parameter | Adjusted OR (95% CI) |
p-Value |
|---|---|---|
| Age | 1.01 (0.98–1.04) | 0.705 |
| SAPS II | 1.03 (0.96–1.10) | 0.414 |
| Chronic pulmonary disease | 3.35 (0.65–17.34) | 0.150 |
| Renal failure | 0.38 (0.11–1.27) | 0.116 |
| Neurological disease | 3.08 (0.95–9.96) | 0.061 |
| Malignant disease | 2.12 (0.56–8.11) | 0.272 |
| Immunosuppression | 3.24 (0.89–11.87) | 0.076 |
| Indwelling urinary catheter | 1.13 (0.32–3.98) | 0.850 |
| Prior hospital stay (3 months) | 0.84 (0.23–3.09) | 0.792 |
| Prior fluoroquinolone use (3 months) | 3.33 (1.10–10.12) | 0.034 |
| Prior amoxicillin/clavulanate use (3 months) | 5.68 (1.97–16.44) | 0.001 |
| Prior carbapenem use (3 months) | 2.26 (0.22–23.31) | 0.493 |
| CO-HCA UTI | 1.77 (0.57–6.48) | 0.320 |
Multivariate logistic regression model was used for examining independent variables associated with amoxicillin/clavulanate resistance, using stepwise automatic variable selection procedure. Only patients with clinical infection (UTI), (n = 212) were included. Abbreviations: 95% CI: 95% confidence interval; SAPS II: simplified acute physiology score II; CO-HCA UTI: community onset-healthcare associated urinary tract infection; UTI: urinary tract infection.