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Afucosylated antibodies have minimal expression of fucose on glycans. LC-MS spectra of trypsin-generated human IgG1 glycopeptides. Glycopeptide species were observed in both triple-charged form (below m/z 1000) and double charged form (above m/z 1000). Top humanized fucosylated hIgG1-TA99 and bottom, afucosylated hIgG1-TA99. Green circle = mannose; yellow circle = galactose; blue square = N-acetylglucosamine; red triangle = fucose; * = unidentified peptide.
