Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 14;22(10):5187. doi: 10.3390/ijms22105187

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Peripheral signals of sense of satiety, after gastric distension, reach the nucleus of the solitary tract/area prostrema complex (NTS/AP) via afferent vagal nerves (green line). The NTS projects to the dorsal motor nucleus (DMN). This pathway modulates glucose production, gastrointestinal motility and hormone release (cholecystokinin, CCK; peptide YY, PYY; glucagon-like peptide-1, GLP-1), and pancreatic secretion via efferent vagal nerves (light blue line). The suggested site of action of vagal nerve stimulation (VNS) is indicated by the dotted purple lines, while the mechanism of weight loss hypothesized vagal nerve blockade (VBLOC) includes a decrease in gastric emptying and inhibition of pancreatic exocrine secretion (dotted red lines) [5].