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Protein–protein interactions predicted through the bioinformatics platform STRINGH. The bioinformatics resource showed interactions of BDNF with ESR1. While TNFα was predicted to interact with both HCK and MCL1. Considering the expression of ESR1 and MCL1 in the hypothalamus, the present bioinformatics prediction suggests that ESR1 and MCL1 could be targets underlying the modulation of BDNF and TNFα induced by the extracts, in HypoE22 cells.
