Table 1.
Features of historical and current biomarkers used for acute myocardial infarction diagnosis.
| Biomarker | TFPT (h) |
TPL (h) |
TRB | Sensitivity (%) * |
Specificity (%) * |
PPV (%) * | NPV (%) * |
|---|---|---|---|---|---|---|---|
| AST | 12–24 | 24–48 | 10–14 days | 75 | 71 | 75 | 71 |
| LDH | 6–12 | 24–72 | 8–14 days | 82 | 70 | 76 | 77 |
| Myoglobin | 0.5–2 | 6–12 | 12–24 h | 79 | 89 | 98 | 60 |
| CK | 3–8 | 12–24 | 48–72 h | 95 | 68 | 30 | 99 |
| CK-MB | 4–8 | 12–24 | 48–72 h | 92 | 90 | 98 | 83 |
| cTn | 3–6 | 10-24 | 5–10 days (TnI) 10–14 days (TnT) |
97–100 | 94–97 | 98–99 | 88–100 |
TFPT—time to first positive test; h—hours; TPL—time to peak levels; TRB—time to return to baseline PPV—positive predictive value; NPV—negative predictive value; AST—aspartate aminotransferase; CK—creatine kinase; CK-MB—creatine kinase-myocardial band; cTn—cardiac troponins (i.e., T and I); LDH—lactate dehydrogenase. * Data reflect values obtained for serial measurement.