Table 3.

A summary of noncanonical interaction partners of FGFR1-4 which have been linked to cancer.

FGFR	Partner	Cancer Subtype	Consequence of Interaction	Associated References
FGFR1	Anosmin-1	Brain; Glioblastoma	Promotes motility and invasion in FGFR-dependent manner	[259]
	Collagen type IV	Pancreatic	Sustained ERK1/2 activation	[10,176,177,260]
	EGFR	Lung	Increases AKT and STAT3 signaling	[261]
	EPHA4	Glioma	Potentiates FGFR1-signaling	[262]
	Galectin-1	Osteosarcoma	Activated FGFR1, increased proliferation and survival	[263]
	Galectin-3	Osteosarcoma	FGFR1 plasma membrane clustering	[263]
	GALNT14	Breast	Promotes FGFR activation	[264]
	Integrin-αVβ3	Breast	Increased tumorigensis, angiogenesis and EMT	[265,266]
	Integrin-β3	Breast	Disrupts colocalization with E-cadherin and promotes EMT	[267]
	L1CAM	Glioma	Promote motility and proliferation	[268,269]
	N-cadherin	Breast	Stabilizes FGFR1 at plasma membrane, promoting sustained ERK1/2 signal, increased invasion, motility and metastasis	[270,271]
	NRP1	Breast	FGFR1-NRP1 complex increases during EMT	[272]
	RET-KIF5B, EGFR	RET-KIF5B fusion positive cancers	Increases FGFR activation and promotes inavdopodia formation	[273]
	TGFBR3	Neuroblastoma	Activates ERK1/2 signaling, promoting differentiation, suppressing tumor growth and metastasis	[274]
FGFR2	EGFR	Breast	Induces EGFR T693 phosphorylation, recycling and stabilization and increases cell cycle outputs	[275]
	EPHA4	Glioma	Increases proliferation and migration	[262]
	RET-KIF5B, EGFR	RET-KIF5B fusion positive cancers	Increases FGFR activation and promotes inavdopodia formation	[273]
FGFR3	PYK2	Multiple myeloma	Increases STAT5 activation	[276]
	TAK1	Multiple myelomaBladder	Cell adhesion and NFκB-dependent transcription	[277]
FGFR4	NCAM	Pancreatic	Promote neurite outgrowth	[278]
	NCAM	Pituitary neoplasia	When interaction is inhibited increases invasive phenotype	[279]

EGFR, epidermal growth factor receptor; EMT, epithelial-mesenchymal transition; EPHA4, ephrin type A receptor 4; ERK1/2, extracellular signal-regulated protein kinase 1/2; FGFR, fibroblast growth factor receptor; L1CAM, L1 cell adhesion molecule; GALNT14, polypeptide N-acetyl galactosaminyltransferase 14; NFκB, nuclear factor κB; NRP1, neuropilin 1; PYK2, focal adhesion nonreceptor protein tyrosine kinase 2; RET-KIF5B, rearranged during transfection (RET)-kinesin family member 5B (KIF5B); STAT3/5; signal transducer and activator of transcription 3/5; TAK1, transforming growth factor α-activated kinase 1; TGFBR3, transforming growth factor receptor β; T693, threonine 693.