Figure 4.

Time of integration of HML7 proviral loci in primate genomes. Temporal overview of the colonization of primate species by HML7 elements, based on the combination of time of integration estimation and comparative genomics analysis of each human locus in non-human primates. Each node indicates a speciation event, and the correspondent time is indicated in the line below. HML7 loci whose insertion occurred in centromeric or pericentromeric regions are marked with a * (Xq11.1) or a + (3q11.2, Yp11.2, 2q11.2 and 12q12), respectively, and their localization in non-human primates could possibly be affected by the lower comparability of constitutive heterochromatin. ¹ Based on multiple approaches of divergence calculation; see materials and methods for further details.