Table 2.
In vitro susceptibility of Candida spp. isolates to Ruta graveolens essential oil and antifungal drugs.
| Strains | Ruta graveolens (REO) (µg/mL) MFC | Amphotericin B (µg/mL) MFC | Fluconazole (µg/mL) MFC | Voriconazole (µg/mL) MFC | ||||
|---|---|---|---|---|---|---|---|---|
| 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | 24 h | 48 h | |
| C. albicans ORL02 | 8.2 ± 0.5 | 12.3 ± 0.5 | 0.5 ± 0.25 | 0.5 ± 0.25 | 0.5 ± 0.25 | 1 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. albicans ORL03 | 8.2 ± 0.5 | 8.2 ± 0.5 | 1 ± 0.5 | 0.5 ± 0.25 | 0.5 ± 0.25 | 1 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. albicans ORL05 | 8.2 ± 0.5 | 12.3 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. albicans ORL07 | 8.2 ± 0.5 | 16.4 ± 0.5 | 1 ± 0.5 | 1.5 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. albicans ORL08 | 8.2 ± 0.5 | 8.2 ± 0.5 | 0.5 ± 0.25 | 0.5 ± 0.25 | 1 ± 0.5 | 1.5 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. albicans ORL09 | 8.2 ± 0.5 | 8.2 ± 0.5 | 0.5 ± 0.25 | 0.5 ± 0.25 | 1 ± 0.5 | 1.5 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. glabrata ORL02 | 131 ± 1 | 131 ± 1 | 2 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 128 ± 2 | 2 ± 0.5 | 4 ± 0.5 |
| C. glabrata ORL11 | 131 ± 1 | 131 ± 1 | 2 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 256 ± 2 | 2 ± 0.5 | 4 ± 0.5 |
| C. glabrata ORL15 | 66 ± 1 | 131 ± 1 | 1 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 128 ± 2 | 1 ± 0.5 | 2 ± 0.5 |
| C. glabrata ORL20 | 131 ± 1 | 131 ± 1 | 2 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 256 ± 2 | 2 ± 0.5 | 4 ± 0.5 |
| C. glabrata ORL22 | 131 ± 1 | 131 ± 1 | 1 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 256 ± 2 | 1 ± 0.5 | 4 ± 0.5 |
| C. glabrata ORL13 | 131 ± 1 | 131 ± 1 | 2 ± 0.5 | 1 ± 0.5 | 128 ± 2 | 256 ± 2 | 2 ± 0.5 | 4 ± 0.5 |
| C. tropicalis ORL18 | 4.1 ± 0.25 | 8.2 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. tropicalis ORL19 | 66 ± 0.5 | 8.2 ± 0.5 | 1 ± 0.5 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. tropicalis ORL20 | 4.1 ± 0.25 | 8.2 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. tropicalis ORL21 | 4.1 ± 0.25 | 8.2 ± 0.5 | 1 ± 0.5 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. tropicalis ORL22 | 4.1 ± 0.25 | 8.2 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. tropicalis ORL23 | 4.1 ± 0.25 | 8.2 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 2 ± 0.5 | 0.03 ± 0.005 | 0.03 ± 0.005 |
| C. parapsilosis ORL25 | 16.4 ± 0.5 | 20.5 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |
| C. parapsilosis ORL25 | 16.4 ± 0.5 | 16.4 ± 0.5 | 1 ± 0.5 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |
| C. parapsilosis ORL27 | 16.4 ± 0.5 | 20.5 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |
| C. parapsilosis ORL28 | 16.4 ± 0.5 | 16.4 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |
| C. parapsilosis ORL29 | 16.4 ± 0.5 | 16.4 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |
| C. parapsilosis ORL30 | 16.4 ± 0.5 | 20.5 ± 0.5 | 0.5 ± 0.25 | 1 ± 0.5 | 2 ± 0.5 | 4 ± 0.5 | 0.125 ± 0.05 | 0.250 ± 0.05 |