Table 2.
Top functions found with IPA associated with the target molecules in the Deseq2 dataset and their respective predicted activation state in Alentejano pigs (AL).
| Functions | p-Value | Activation z-Score | Predicted Activation in AL | Target Molecules |
|---|---|---|---|---|
| Quantity of cells | 3.64 × 10−2 | 2.185 | Increased | IL12RB1, ITPR1, KDM2B, LSP1, MAP3K14, PSMB9, SPHK2, THRA, TRIB1 |
| Neuronal cell death | 1.69 × 10−2 | −2.164 | Decreased | ITPR1, KDM2B, P4HB, SLC9A1, UCN |
| Quantity of leukocytes | 1.75 × 10−3 | 2.152 | Increased | IL12RB1, ITPR1, LSP1, MAP3K14, PSMB9, SPHK2, THRA, TRIB1 |
| Apoptosis of tumour cell lines | 1.32 × 10−2 | −2.043 | Decreased | ITPR1, KDM2B, LSP1, MAP3K14, P4HB, SLC9A1, SPHK2, THRA |
| Binding of DNA | 1.77 × 10−2 | 1.993 | - | CBX1, MAP3K14, THRA, UCN |
| Cell cycle progression | 3.52 × 10−2 | 1.964 | - | ANGEL2, CSNK1D, KDM2B, SLFN11, SPHK2, THRA |
| Quantity of macrophages | 1.08 × 10−3 | 1.961 | - | IL12RB1, LSP1, THRA, TRIB1 |
| Quantity of B lymphocytes | 9.65 × 10−3 | 1.190 | - | ITPR1, MAP3K14, SPHK2, THRA |
| Synthesis of lipid | 3.57 × 10−2 | 1.186 | - | MAP3K14, PTGES2, RUFY1, SPHK2, TRIB1 |