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. 2021 May 17;10(5):442. doi: 10.3390/biology10050442

Figure 6.

Figure 6

Effect of camel milk administration on the renal protein expression of MMP-2 in cyclosporine-evoked renal damage in rats. (A–E) Evaluation of the renal expression of matrix metalloproteinase-2 (MMP-2) by the immunohistochemical staining (×400 magnification). Representative photomicrographs depicting minimal expression of MMP-2 in the control (A) and camel milk-treated control (B) groups. CsA administration triggered an increased expression of MMP-2 (positive brown staining is indicated by an arrow; (C), which was attenuated in camel milk-treated renal injury group (D) and quercetin-treated renal injury group (E). (F) Quantification of the immunostaining of MMP-2 (optical density) in all groups. Values are displayed as mean ± SEM, for 4 samples per group. The immunostaining was examined across 6 non-overlapping fields per section. * Significance vs. control values at p < 0.05; # Significance vs. CsA values at p < 0.05. CsA, cyclosporine (20 mg/kg/day, s.c., for 3 weeks); CM 10, camel milk (10 mL/kg/day, by gavage, for 3 weeks); QRC; the reference antioxidant quercetin (50 mg/kg/day, by gavage, for 3 weeks).