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. 2021 May 17;22(10):5262. doi: 10.3390/ijms22105262

Figure 7.

Figure 7

Analysis of CFTR subcellular localization. (A,B) Representative images showing the detection of F508del-CFTR or wild type CFTR protein in CFBE41o- cells by immunofluorescence. Cells were incubated with vehicle (DMSO) or with the corrector combination (5 µM VX-445 plus 1 µM VX-809) for 24 h. Cells were immediately fixed or treated for the indicated time (1–6 h) with CHX and then fixed (scale bar: 15 µm). (C) Analysis of CFTR protein expression in the plasma membrane at different times following CHX addition. **, p < 0.01; ***, p < 0.001.