Table 1.

Summary of inflammatory reaction in each skin inflammation disease model.

	Psoriasis	AD	Contact Dermatitis
Gluten or wheat	Gluten free diet CD4+ cell infiltration ↓ [34] IFN-γ, IL-12, IL-17 ↓ [35]	Gluten: TSLP ↑ [40] Salt soluble wheat protein: TNF-α, IFN-γ, IL-1β, IL-4, IL-10, IL-13, IL-17, CCL1, CCL5, CCL11, CCL12, CCL22, CCL24, CXCL9, CXCL16, E-selectin ↑ [39]
Fiber	Dietary fiber: Treg ↓ [45] Butyrate:IL-17, IL-6↓IL-10 ↑ [46]		Butyrate: Treg ↑ IL-6 ↓ [49], IL-10 ↑ [49,50].
Lipid	LTB4: Neutrophil migration, IL-19 ↑ [53], DC migration↑ [31], IFN-γ ↑ [54] TxA2: IL-17 ↑ [56]. EPA: TNF-α, IL-1β ↓ [57]. RvE1: IL-17, IL-23, IL-12b ↓ [58] MaR1: IL-17 ↓ [59] RvD1: IL-23, IL-22, IL-17, TNF-α ↓ [60].	EPA/DHA: IL-13, IL-17, LTB4, T cell migration ↓ [65] RvE1: IFN-γ, IL-4, IgE ↓ [66] LTB4: IL-4, IL-13, CD4 migration↑ [69] PGE2-EP2: TSLP ↓ [70]	DHA: IFN-γ, IL-6, IL-1β, IL-2↓ [72] EPA/DHA: TNF-α, IL-2, IL-4, IL-12 ↓ IL-10 ↑ [73] RvE1: DC migration ↓ [31,74], IFN-γ ↓ [31] PGE2-EP3: CXCL1 ↓ [75] PGE2-EP4: LC maturation, migration ↑ [76]. PGE2-EP2/EP4: IL-22 ↑ [77]
Smoking	IFN-γ, IL-17A ↑ [83]	IL-13 ↑ [92],, IL-4 ↑ [93]	IFN-γ ↑ [99,100,101] Nicotine: DC maturation, T cell activation/migration ↓ [102]
Alcohol	Ethanol: IFN-γ, TNF-α, IL-6 ↑ [105], Lymphocyte proliferation ↑ [106]	Ethanol: Histamine ↓ [111] Acetaldehyde: Histamine ↑ [113]
Sleep disturbance	IL-17 ↑ [117]	Skin hydration ↓ [120]	Mast cell, IgE↑ [121]
Obesity	Th17 ↑ [125,126]	Skin burrier ↓ [129], TSLP ↑ [70]	Lymphatic vessel disfunction [131,132], IFN-γ ↑ [122]

Note: ↑: increase, ↓: decrease.