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. 2021 May 14;11(5):319. doi: 10.3390/metabo11050319

Figure 1.

Figure 1

Cold exposure physiologically induces the browning process by sympathetic fiber innervation via a β3-adrenergic stimulation of white adipose tissue (WAT). The beige phenotype, enriched with mitochondria, allows for non-shivering thermogenesis like brown adipocytes due to the expression of UCP1. Photographs represent hematoxylin and eosin (HE) staining of WAT, WAT-derived brown-like adipose tissue (wBAT) and brown adipose tissue (BAT) in mice.