Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 16;22(10):5247. doi: 10.3390/ijms22105247

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

BMAL1 deregulation in colorectal carcinomas (CRC) is associated to epithelial–mesenchymal transition (EMT) and cancer invasiveness perturbations. (A) Boxplot of mRNA expression (Z-scores, RNAseq) in tumors of CRC with patients stratified on their BMAL1 quantification. (B) Enrichment for hallmark EMT gene sets in CRC tumors of patients with a high level of BMAL1 (NES: Normalized Enrichment Score). (C) Principal component analysis performed with EMT-enriched genes found deregulated in CRC tumor samples. (D) Expression heatmap of EMT genes connected to BMAL1 in CRC tumors. (E) Enrichment of multicancer invasiveness signature in CRC tumors of patients with a high level of BMAL1 (NES: Normalized Enrichment Score). (F) Principal component analysis performed with cancer invasiveness-enriched genes found deregulated in CRC tumor samples. (G) Expression heatmap of cancer invasiveness genes connected to BMAL1 in CRC tumors.