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Schematic representation of the genome editing tools for thermophilic microorganisms. The Zinc finger nuclease is the first genome editing tool setup for thermophilic microorganisms. The most common is the spontaneous homologous recombination. In the last decades, the Cre/lox and CRISPR-Cas based tools were adapted for thermophiles (Created with BioRender.com (accessed on 20 January 2021)).
