Table 1.
Compositions used for preparing placebo films.
| Batch Code | Proloc (% w/v) |
HPMC F4M (% w/v) |
HPMC K100M (% w/v) |
HPMC K4M (% w/v) |
Eudragit RS 100 (% w/v) |
PEG 200 (% w/v) |
PG (% w/v) |
Tween 80 (% w/v) |
Film Properties |
|---|---|---|---|---|---|---|---|---|---|
| FR1 | 10 | - | - | - | 15 | 2.5 | 2.5 | 0.5 | Non-homogenous film formed after drying |
| FR2 | 8 | 2 | - | - | 15 | 2.5 | 2.5 | 0.5 | Small cracking occurred after drying |
| FR3 | 6 | 4 | - | - | 15 | 2.5 | 2.5 | 0.5 | Films formed were non-tacky, peelable and possessed enough mechanical strength |
| FR4 | 4 | 6 | - | - | 15 | 2.5 | 2.5 | 0.5 | Films formed were non-tacky, peelable and possessed enough mechanical strength |
| FR5 | 8 | - | 2 | - | 15 | 2.5 | 2.5 | 0.5 | Films formed were non-tacky, peelable and possessed enough mechanical strength |
| FR6 | 6 | - | 4 | - | 15 | 2.5 | 2.5 | 0.5 | Films formed were sticky |
| FR7 | 4 | - | 6 | - | 15 | 2.5 | 2.5 | 0.5 | Films formed were thick |
| FR8 | 8 | - | - | 2 | 15 | 2.5 | 2.5 | 0.5 | Small cracking occurred after drying |
| FR9 | 6 | - | - | 4 | 15 | 2.5 | 2.5 | 0.5 | Films formed were non-tacky, peelable and possessed enough mechanical strength |
| FR10 | 4 | - | - | 6 | 15 | 2.5 | 2.5 | 0.5 | Films formed were sticky |
HPMC: hydroxypropyl methylcellulose; PEG: polyethylene glycol; PG: propylene glycol.