Figure 3.
G9a promotes hepatocellular carcinoma (HCC) growth in an orthotopic mouse model. Luciferase-tagged Mahlavu cells with stable expression of control or G9a shRNA were orthotopically injected into the liver of 8-week-old NOD/SCID mice, and animals were sacrificed 6 weeks after tumor implantation. (A) Cancer growth of Mahlavu xenografts was imaged with bioluminescence at the end of the study. (B) Quantitative analysis of imaging signal intensity (photons/s/cm2/sr), with the mean signal for each group indicated.