Figure 3.

Pedigree of Index Fabry Patient 5 and 7. Circles are women and squares are men. Filled symbols are affected patients with GLA IVS4 + 919G > A mutation. Empty symbols are unaffected relatives without mutation. Dotted females are asymptomatic carriers. Dashed symbols are deceased family members. Question marks indicate family members with an unknown genotype as a genetic test was not performed. Numbers are ages. Index patients are indicated by triangles. AF = atrial fibrillation; DM = diabetes; HCM = hypertrophic cardiomyopathy; HF = heart failure; HT = hypertension; LVH = left ventricular hypertrophy.