Fig. 3.

Cumulative incidence of persistent alkaline phosphatase change (initial: The initial persistent SAP group change defined by the first occurrence of 2 or more SAP values measured at least 3 months apart that differed from baseline group). a Individuals with normal alkaline phosphatase at diagnosis who subsequently develop an abnormal alkaline phosphatase; b individuals with an abnormal alkaline phosphatase at diagnosis who subsequently develop a normal alkaline phosphatase; c individuals with an alkaline phosphatase ≥ 1.5 times the upper limit of normal at diagnosis who subsequently develop an alkaline phosphatase value below this threshold