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. Author manuscript; available in PMC: 2021 May 27.
Published in final edited form as: J Hepatol. 2020 Sep 17;74(2):394–406. doi: 10.1016/j.jhep.2020.09.010

Fig. 3. Effect of SAMe administration on hepatic cystogenesis and fibrosis in PCK rats.

Fig. 3.

(A) Physical parameters and serum albumin levels in WT (n = 8) and PCK (untreated [n = 14] and SAMe-treated [n = 12]) rats. (B) Representative liver images (scale bar: 1 cm), H&E and picrosirius red staining (scale bar: 500 μm). (C) Hepatic cystogenesis and fibrosis quantification in PCK (untreated and SAMe-treated) rats. (D) Representative IHC images of SUMO1 and UBC9 in rat liver tissue. (E) 3D-cultured PCK cysts in the presence/absence of SAMe (n = 12) (T0: time zero). *p <0.05; **p <0.01; ***p <0.001 (one-way ANOVA, Kruskal-Wallis, Mann-Whitney or 2-tailed t-tests, except fibrosis [one-tailed t test]). IHC, immunohistochemistry; PCK, polycystic: SAMe, S-adenosylmethionine; WT, wild-type.