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. 2020 Jan 28;11(9):2524–2530. doi: 10.1039/c9sc05937g

Accumulation of Gd and Pt in A2780 and HeLa cells when incubated with GP1, GP2, cisplatin, and carboplatin near their IC50 concentrations and 1 at 100 μM for 24 h.

Complex Cell accumulation (fmol per cell)
A2780 cells HeLa cells
Gd Pt Gd Pt
GP1 2.5 ± 0.3 0.20 ± 0.03 5.7 ± 1.9 0.17 ± 0.01
GP2 1.4 ± 0.2 0.38 ± 0.1 1.1 ± 0.2 0.30 ± 0.06
1 0.26 ± 0.02 N/A 0.21 ± 0.01 N/A
Cisplatin N/A 0.21 ± 0.02 N/A 0.27 ± 0.02
Carboplatin N/A 0.22 ± 0.02 N/A 0.60 ± 0.11