Accumulation of Gd and Pt in A2780 and HeLa cells when incubated with GP1, GP2, cisplatin, and carboplatin near their IC50 concentrations and 1 at 100 μM for 24 h.
Complex | Cell accumulation (fmol per cell) | |||
---|---|---|---|---|
A2780 cells | HeLa cells | |||
Gd | Pt | Gd | Pt | |
GP1 | 2.5 ± 0.3 | 0.20 ± 0.03 | 5.7 ± 1.9 | 0.17 ± 0.01 |
GP2 | 1.4 ± 0.2 | 0.38 ± 0.1 | 1.1 ± 0.2 | 0.30 ± 0.06 |
1 | 0.26 ± 0.02 | N/A | 0.21 ± 0.01 | N/A |
Cisplatin | N/A | 0.21 ± 0.02 | N/A | 0.27 ± 0.02 |
Carboplatin | N/A | 0.22 ± 0.02 | N/A | 0.60 ± 0.11 |