Table 1.
RBP | Domain [22] | Binding Motif [23,24] | |
---|---|---|---|
RBM | more than one RRM ZF domain (RBM4, 4B, 5, 10, 20, 22, 26, 27) |
GCGC(G) | RBM4, 4B, 8A |
GAAGG | RBM5 | ||
AUCCA | RBM6 | ||
GUGUG | RBM24, 38 | ||
GUAG | RBM28 | ||
UACA/UU | RBM41 | ||
AACUA | RBM42 | ||
GACGAC | RBM45 | ||
AUC/GA | RBM46, 47 | ||
AUAUA | RBMS1, S2, S3 | ||
CCA/C | RBMX | ||
CU/ACAA | RBMXL1, XL2, XL3, Y1A1, Y1B, Y1D, Y1E, Y1F, Y1J | ||
hnRNP | one to three RRMs (except hnRNP E, F, H, K, U) three qRRMs (hnRNP F, H)three KH domains (hnRNP E, K)acidic-rich domain (hnRNP C, Q, R, U) |
UAGGG | hnRNP A1, A1L2, A2B1, A3 |
UUUUU | hnRNP C, CL1 | ||
GGGAGG | hnRNP F, H1, H2 | ||
CCAA/UC/ACC | hnRNP K | ||
ACAC | hnRNP L | ||
ACANACA | hnRNP LL | ||
UAAU/AU/A | hnRNP DL | ||
TDP-43 | two RRMs, G-rich region | GAAUG | |
FET proteins | RRM, three RGG boxes, SYGQ-rich region, ZF domain | poly(G) | |
ELAV/Hu family | three RRMs, hinge region | poly(U) | |
CELF | three RRMs, hinge region | GUGU | |
RCAN | RRM, LxxP motif, PxIxIT-like motif, TxxP motif | n.d. | |
Msi | two RRMs | UAG | |
FMRP | two KH domains, RGG box | GAC | |
TIA | three RRMS, Q-rich domain | poly(U) | |
TTP | two ZF domains, | AU-rich | |
SRSF | one or two RRMs, RS domain | GGAGGA/G | SRSF 1, 2, 4, 6, 9 |
(A)GCAG(C) | SRSF 2, 4, 5, 8, 10 | ||
GA/GUCAACCNGGCGACA/CG | SRSF 4, 6 | ||
NOVA | three KH domains | U/CCAU/C | |
Matrin3 | two RRMs, two ZF domains | AUCUU | |
PABP | one or four RRMs | poly(A) | |
SAFB | SAP domain, RRM, RG/RGG domain | AG-rich |