Table 1.

List of domains and estimated binding motifs of RBPs based on the protein database.

RBP	Domain [22]	Binding Motif [23,24]
RBM	more than one RRM ZF domain (RBM4, 4B, 5, 10, 20, 22, 26, 27)	GCGC(G)	RBM4, 4B, 8A
		GAAGG	RBM5
		AUCCA	RBM6
		GUGUG	RBM24, 38
		GUAG	RBM28
		UACA/UU	RBM41
		AACUA	RBM42
		GACGAC	RBM45
		AUC/GA	RBM46, 47
		AUAUA	RBMS1, S2, S3
		CCA/C	RBMX
		CU/ACAA	RBMXL1, XL2, XL3, Y1A1, Y1B, Y1D, Y1E, Y1F, Y1J
hnRNP	one to three RRMs (except hnRNP E, F, H, K, U) three qRRMs (hnRNP F, H)three KH domains (hnRNP E, K)acidic-rich domain (hnRNP C, Q, R, U)	UAGGG	hnRNP A1, A1L2, A2B1, A3
		UUUUU	hnRNP C, CL1
		GGGAGG	hnRNP F, H1, H2
		CCAA/UC/ACC	hnRNP K
		ACAC	hnRNP L
		ACANACA	hnRNP LL
		UAAU/AU/A	hnRNP DL
TDP-43	two RRMs, G-rich region	GAAUG
FET proteins	RRM, three RGG boxes, SYGQ-rich region, ZF domain	poly(G)
ELAV/Hu family	three RRMs, hinge region	poly(U)
CELF	three RRMs, hinge region	GUGU
RCAN	RRM, LxxP motif, PxIxIT-like motif, TxxP motif	n.d.
Msi	two RRMs	UAG
FMRP	two KH domains, RGG box	GAC
TIA	three RRMS, Q-rich domain	poly(U)
TTP	two ZF domains,	AU-rich
SRSF	one or two RRMs, RS domain	GGAGGA/G	SRSF 1, 2, 4, 6, 9
		(A)GCAG(C)	SRSF 2, 4, 5, 8, 10
		GA/GUCAACCNGGCGACA/CG	SRSF 4, 6
NOVA	three KH domains	U/CCAU/C
Matrin3	two RRMs, two ZF domains	AUCUU
PABP	one or four RRMs	poly(A)
SAFB	SAP domain, RRM, RG/RGG domain	AG-rich