Table 2.
List of interactions between the RBPs and miRNAs in the ALS and the FTD.
| Associated RBPs | Related miRNAs | Target Gene(s) | Relation between RBPs and miRNAs | miRNA Abnormalities in Diseases |
|---|---|---|---|---|
| TDP-43 | miR-181c-5p | TDP-43 | forms a negative feedback loop in miRNA processing [124] | is reduced in the spinal cord of ALS patients [125] |
| miR-27b-3p | ||||
| miR-8485 | NRXN1 | forms an miRISC complex to decrease genes related to synaptic formation [126] | n.d. | |
| FUS/TDP-43 | miR-183/96/182 | PP1 | regulates miRNA biogenesis, which is related to memory formation [129] | is reduced in the frontal cortex of ALS patients [129] |
| TAF15 | miR-17-92 | CDKN1A/p21 | regulates miRNA biogenesis to decrease genes related to cell proliferation [132] | is reduced in an SOD1G93A mouse model [133] |
| hnRNP A1 | miR-590-3p | n.d. | is cooperatively regulated in neuronal maintenance ? [135] | is increased in the blood cells of FTD patients [135] |
| hnRNP H | miR-663a | CDK4, CDK6 | is cooperatively regulated in cellular senescence by targeting genes related to the cell cycle [137] | is increased in the blood cells of ALS patients [138] |
| RALY | miR-483 | ATP5I, ATP5G1, ATP5G3, CYC1 | regulates miRNA biogenesis to decrease genes related to mitochondrial metabolism [140] | n.d. |
| miR-676 | ||||
| miR-877 | ||||
| RBM17 | miR-150-5p | VEGF-A | is cooperatively regulated in genes related to growth factors [143] | is reduced in the CSF of ALS patients [145] |
| HuD | miR-125a-5p | CAMSAP3 | cooperatively regulates circRNA in aging by targeting genes related to neuronal polarization [148] | is reduced in aging mice [147] |
| Matrin-3 | miR-138-5p | n.d. | inhibits miRNA biogenesis in the regulation of neuronal development [152] | n.d. |
n.d.: not detected.