Table 5.
List of interactions between the RBPs and miRNAs in HD and MSA.
| Disease | Associated RBPs | Related miRNAs | Target Gene(s) | Relation between RBPs and miRNAs | miRNA Abnormalities in Diseases |
|---|---|---|---|---|---|
| HD | SRSF6 | miR-193a-5p | OGDHL, ECM1 | forms a negative feedback loop in cancer cell migration and invasion by regulating alternative splicing [217] | is decreased in the blood of Autism patients [218] |
| PTBP1 | miR-195-5p | ETV1 | competitively regulates circRNA in BTB permeability by targeting genes related to tight junction [220] | is decreased in the brain and CSF of AD patients [222] | |
| miR-186-5p | Occludin | competitively regulates circRNA in BTB permeability by targeting genes related to tight junction [221] | is decreased in the brain of aged mouse [224] | ||
| hnRNP K | miR-107 | Bcl2l2 | promotes miRNA activation via circRNA in neuronal apoptosis by targeting apoptotic regulating genes [225] | is decreased in the brain of AD patients [226] | |
| HuR | miR-7 | n.d. | regulates miRNA biogenesis, which is related to neuronal differentiation [107] | is elevated in the brain of AD patient [156] | |
| SAFB1 | miR-19a | n.d. | regulates miRNA biogenesis [229] | is decreased in a cellular model of HD [230] | |
| MSA | NOVA1 | miR-96-5p | GTRAP3-18 | inhibits RBPs regulating neuroprotection and targeting neurotoxic genes [231] | is decreased in the frontal cortex of MSA patients [232] |
n.d.: not detected.