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. 2021 May 18;13(5):1703. doi: 10.3390/nu13051703

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The structure of vitamin A and retinoids. The retinoids represented belong to the four described generations. First-generation compounds are found in the diet, except for some natural metabolites formed in the body. Members of the 2nd, 3rd and 4th generations are synthetic derivates based on the original retinoic structure and are used in treating different diseases. All retinoids possess a common structure and similar physicochemical properties, although their effects on the human body can vary greatly.