Figure 1: NLRP3 Inflammasome Pathway and Therapeutic Targets.

Canonical NLRP3-inflammasome pathway in atherosclerotic disease and potential targets for emerging therapeutic anti-inflammatory agents. ASC = apoptosis associated with speck-like protein; ATP = adenosine triphosphate; CPPD = calcium pyrophosphate dihydrate; CRP = C-reactive protein; Fib = fibrinogen; IL = interleukin; NF-κB = nuclear factor κB; NLRP3 = NOD- (nucleotide oligomerisation domain), LRR (leucine-rich repeat), PYD (pyrin domain)-containing protein 3; P2X7 = purinoceptor 7; PAI-1 = plasminogen activator inhibitor 1; ROS = reactive oxygen species. Source: Some of the icons in this image are reproduced from Servier Medical Art by Servier. Reproduced from Servier Medical Art by Servier under a Creative Commons (CC BY 4.0) licence.