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Fig. 2. (a) DLS and TEM (inset) analyses of LSNPs in the dark and after applying 450 nm irradiation for different time intervals. (b) Fluorescence spectra of DOX-loaded LSNPs left in the dark, and after irradiation with 450 nm light for 30 min. (c) In vitro drug release profiles of DOX-loaded LSNPs at pH 7.4 or pH 5.0 left in the dark and after irradiation with 450 nm light (irradiation for 5 min per hour for the first 6 h).