Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Main molecular mechanisms induced by glucagon-like peptide-1 (GLP-1) to protect beta-cells from apoptosis. Beta-cell stressors (such as increased IAPP, gluco- and/or lipotoxicity) may trigger ER stress, alter mitochondrial function and/or the autophagic flux and modify gene expression. GLP-1 and GLP-1RA have been reported to protect beta-cells by alleviating these deleterious effects.
