Table 1.
Phospholipids in non-tumor (NT) and tumor tissues (TT) of the 10 HBV, 11 HCV and 3 double-infected patients. Levels of saturated PE and PS were below 0.001 nmol/mg and are not included. Lipid concentrations (nmol/mg) are given as median values and range. Phosphatidylcholine, PC; phosphatidylethanolamine, PE; phosphatidylinositol, PI; phosphatidylserine, PS; polyunsaturated, PU; saturated, sat. * p < 0.05 and ** p < 0.01 and *** p < 0.001 compared to the respective NT using a paired Students’ t-test. Significantly different lipid levels in NT and TT are in bold.
| HBV | HCV | HBV/HCV | ||||
|---|---|---|---|---|---|---|
| NT | TT | NT | TT | NT | TT | |
| Sat. PC |
0.23
(0.18–0.32) |
0.49 *
(0.15–1.00) |
0.28
(0.18–0.55) |
0.43 *
(0.11–1.08) |
0.29 (0.26–0.34) |
0.32 (0.12–0.70) |
| PU-PC |
10.2
(6.5–14.7) |
5.9 ***
(3.2–8.6) |
8.4 (3.3–10.2) |
7.6 (0.6–16.8) |
9.6 (7.6–11.1) |
7.5 (1.7–10.6) |
| PU-PE |
7.2
(3.8–9.9) |
4.7 **
(0.1–8.0) |
5.0 (1.7–6.9) |
6.4 (0.1–10.6) |
5.4 (5.1–7.2) |
6.8 (1.1–7.1) |
| PC/PE | 1.7 (1.6–2.2) |
2.1 (1.5–74.6) |
2.1 (1.7–3.0) |
1.9 (1.7–12.4) |
2.0 (1.8–2.1) |
2.1 (1.9–2.1) |
| Sat. PI | 0.02 (0.01–0.03) |
0.01 (0.00–0.03) |
0.02 (0.01–0.05) |
0.03 (0.00–0.07) |
0.02 (0.02–0.02) |
0.02 (0.01–0.10) |
| PU-PI | 3.9 (2.3–5.6) |
4.1 (0.1–6.4) |
3.0
(1.4–4.8) |
4.7 *
(0.1–9.6) |
3.8 (3.5–4.2) |
5.6 (0.8–7.8) |
| PU-PS |
1.8
(1.1–2.2) |
1.2 ***
(0.1–1.9) |
1.4 (0.7–1.8) |
1.5 (0.1–2.2) |
1.7 (1.4–1.8) |
1.2 (0.6–1.6) |
| Sat. LPC | 0.07 (0.04–0.10) |
0.08 (0.04–5.81) |
0.06 (0.02–0.26) |
0.06 (0.03–0.10) |
0.08 (0.07–0.18) |
0.04 (0.02–0.05) |
| PU-LPC | 0.40 (0.23–0.86) |
0.38 (0.21–0.81) |
0.17 (0.06–0.31) |
0.14 (0.07–0.29) |
0.06 (0.05–0.13) |
0.03 (0.01–0.05) |