Skip to main content
. 2021 May 18;13(10):2438. doi: 10.3390/cancers13102438

Figure 2.

Figure 2

Loss of Pgrmc1 extends the survival duration and suppresses the development of mice bearing hepatocellular carcinoma (HCC). (A) Kaplan–Meier curve of wild-type (WT) and Pgrmc1 knockout (KO) mice bearing HCC. For the induction of HCC, mice were injected with diethylnitrosamine (DEN) (25 mg/kg, i.p.) at 2-week-old of age, and their survival rate was monitored until 104 weeks. (B) Gross images of the livers of WT and Pgrmc1-null mice with DEN-induced HCC. Mice (2-weeks-old) were injected with DEN (25 mg/kg/week, i.p.) once a week for 4 weeks and sacrificed at 50 weeks for tumor assessment. Scale bar, 0.5 cm. (C) Tumor incidence at 50-weeks-old WT (n = 11) and Pgrmc1 KO (n = 12) mice with DEN-induced HCC. (D) Plasma ALT level in 50-weeks-old WT and Pgrmc1 KO mice with DEN-induced HCC. * p < 0.05 in Student’s t-test. (E) Tumor number, (F) individual tumor size, and (G) average tumor size in the livers of 50-week-old WT and Pgrmc1 KO mice with DEN-induced HCC. * p < 0.05 in Student’s t-test.